Unprecedented hetero-geometric discrete copper(II) complexes: Crystal structure and bio-mimicking of Catecholase activity
| Autor: | Abhranil De, Milan Maji, Bhaskar Biswas, Angshuman Roy Choudhury, Hare Ram Yadav, Ramakant Mahadeo Kadam, Vinayak Rane, Dhananjay Dey |
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| Rok vydání: | 2016 |
| Předmět: |
Catechol
biology Semiquinone Thiocyanate 010405 organic chemistry Active site General Chemistry 010402 general chemistry Photochemistry 01 natural sciences 0104 chemical sciences law.invention Turnover number chemistry.chemical_compound Catalytic cycle chemistry law Polymer chemistry biology.protein Catechol oxidase Electron paramagnetic resonance |
| Zdroj: | Journal of Chemical Sciences. 128:1775-1782 |
| ISSN: | 0973-7103 0974-3626 |
| DOI: | 10.1007/s12039-016-1186-x |
| Popis: | An unprecedented solid of coper(II) complexes, [Cu(dpa)2NCS]2[Cu(dpa)2(NCS)2](ClO4)2 (1) [dpa = 2,2′-dipyridylamine; SCN = thiocyanate], has been synthesized and crystallographically characterized with the aim to study the catecholase activity. The Cu(II) complex mimics the full catalytic cycle of the active site of catechol oxidase enzyme in acetonitrile medium with a turnover number of 4.788×103 h −1 along with the production of semiquinone radical and hydrogen peroxide. In situ generation of Cu(I) species in the catalytic pathway of catechol oxidation was established by electrochemical study and further confirmed by electron paramagnetic resonance (EPR) spectroscopy. |
| Databáze: | OpenAIRE |
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