Once-Daily Cetirizine Is Safe and Effective for Children with Allergic Rhinitis with and without Intermittent Asthma
| Autor: | Eli O. Meltzer, Dial Hewlett, Bruce M. Prenner, Douglass Chapman, Richard F. Lockey, David G. Tinkelman, Don Q. Mitchell, Allen T. Segal, Benjamin Kramer |
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| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry medicine.drug_class Placebo medicine.disease Cetirizine Pulmonary function testing Internal medicine Concomitant Pediatrics Perinatology and Child Health medicine Immunology and Allergy Once daily Adverse effect business H1 antagonist medicine.drug Asthma |
| Zdroj: | Pediatric Asthma, Allergy & Immunology. 16:265-274 |
| ISSN: | 1557-7767 0883-1874 |
| Popis: | The prevalence of seasonal allergic rhinitis among 1 to 12 year olds is between 10% and 20%. Cetirizine is a selective, once-daily H1 antagonist approved for the treatment of seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria in adults and children 2 years and older, and was recently approved for the treatment of perennial allergic rhinitis and chronic urticaria in children down to 6 months of age. This randomized, multicenter, double-blind, placebo-controlled study enrolled 172 children with seasonal allergic rhinitis, including a large subgroup with concomitant asthma. Cetirizine syrup or placebo were administered for 2 weeks. Cetirizine 10 mg once daily provided significant relief from symptoms of seasonal allergic rhinitis, both in children with and without concomitant asthma. Among subjects with asthma, the frequency and severity of asthma symptoms were similar between the cetirizine and placebo groups. Cetirizine caused no adverse effects on pulmonary function ... |
| Databáze: | OpenAIRE |
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