Synthesis of the Hydrazinyl Pyridine Intermediate: Phase-Appropriate Delivery
| Autor: | Andrew Cosbie, Steven M. Mennen, Ashraf Wilsily, Jacqueline E. Milne |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
010405 organic chemistry business.industry Supply chain Organic Chemistry Process (computing) Raw material 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Phase (matter) Pyridine Physical and Theoretical Chemistry Process engineering business |
| Zdroj: | Organic Process Research & Development. 21:1286-1293 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.7b00172 |
| Popis: | A two-step synthesis of an intermediate for a drug-candidate, 3-fluoro-2-hydrazinyl-5-(1-methyl-1H-pyrazol-4-yl)pyridine (1), was developed and optimized according to the strategic priorities of the program. The bond disconnection remained unchanged from the initial route to the scale-up routes; however, the process evolved as the program’s priorities progressed. Speed, securing the raw material supply chain, and cost were all factors considered during development. The strategies to enable multikilogram deliveries are highlighted in this report. |
| Databáze: | OpenAIRE |
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