18F-FDG PET/CT in Patients with Parenchymal Changes Attributed to Radiation Pneumonitis
| Autor: | Irena Dimitrova Kostadinova, Iliya Rumenov Gabrovski, Anastas Demirev |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Chemotherapy Lung medicine.diagnostic_test business.industry medicine.medical_treatment Mediastinum medicine.disease 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Positron emission tomography 030220 oncology & carcinogenesis Parenchyma medicine Carcinoma Radiology Nuclear Medicine and imaging Radiology Complication business |
| Zdroj: | Molecular Imaging and Radionuclide Therapy. 27:107-112 |
| ISSN: | 2147-1959 2146-1414 |
| DOI: | 10.4274/mirt.55706 |
| Popis: | Objectives Radiation pneumonitis (RP) can be an adverse complication of radiotherapy (RT) and can limit the application of the already planned radiation dose. It is often associated with RT of lung carcinoma and is occasionally caused by radiation therapy of breast carcinoma and lymphomas located in the mediastinum. Positron emission tomography/computed tomography (PET/CT) emerges lately as a prospective modality for early diagnostics of RP. The aim of this study was to summarize the initial data from diagnostic application of PET/CT in patients suspicious of RP and to derive criteria, which can help differentiate RP from early recurrence of the disease and/or residual tumor. Methods The current study included 23 patients who had metabolic (PET) and anatomical (CT) changes consistent with RP. We additionally defined metabolic activity (SUVmax) in the lung parenchyma of 20 patients without RT. Results All patients had increased metabolic activity in the lung parenchyma involved in the irradiated area with a mean SUVmax 3.45 (ranging between 1 and 7.1). The control group had a physiological background metabolic activity-SUVmax 0.61 +/- 0.11. Conclusion Metabolic changes in patients suspicious of RP involved diffusely increased metabolic activity coinciding with the anatomical changes in the irradiated area. Three out of 23 patients had a proven recurrence of the primary neoplastic process in the irradiated area. The metabolic changes in those patients involved an increase in metabolic activity at follow-up or lack of tendency towards normalization after chemotherapy, which implied the existence of viable tumor cells. Our initial experience in the diagnostic application of 18F-FDG PET/CT in patients suspicious of RP allows us to summarize the following: PET/CT is a reliable imaging modality in the diagnostics of RP. Through its sequential use, we can differentiate inflammatory changes related to RP from early recurrence of the primary neoplastic process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|