Rearrangement in the Series of Acetyltetrahydropyridine Derivatives

Autor:	Kh. A. Asadov, İbrahim G. Mamedov, Farid N. Naghiyev, Abel M. Maharramov
Rok vydání:	2019
Předmět:	chemistry.chemical_compound chemistry 010405 organic chemistry Organic Chemistry Michael reaction Ethylenediamine Nuclear magnetic resonance spectroscopy Methanol Acetoacetanilide 01 natural sciences Medicinal chemistry 0104 chemical sciences
Zdroj:	Russian Journal of Organic Chemistry. 55:388-391
ISSN:	1608-3393 1070-4280
Popis:	Michael addition of various substituted benzylidene- and thiophen-2-ylmethylidenemalononitriles with acetoacetanilide gave the corresponding 5-acetyl-2-amino-4-aryl(hetaryl)-6-oxo-1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonitriles. Treatment of the latter with ethylenediamine in boiling methanol resulted in their rearrangement with elimination of the acetyl group and formation of 2-anilino-4-aryl(hetaryl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles. The product structure was proved by NMR spectroscopy and X-ray analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f3641580bde38cdfddedc59135844bd https://doi.org/10.1134/s1070428019030217 Zobrazit plný text záznamu Plný text ve formátu PDF