Cutting Edge: B Cell–Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection
| Autor: | Galit Alter, Diana Chen, Ryan P. Staupe, John R. Teijaro, E. John Wherry, Pamela M. Odorizzi, Alison E. Mahan, Burton E. Barnett, Steven L. Reiner, Olesya Palko, Bronwyn M. Gunn, Georg M. Lauer, Vesselin T. Tomov, Michael A. Paley |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Glycosylation biology medicine.diagnostic_test Immunology hemic and immune systems chemical and pharmacologic phenomena Lymphocytic choriomeningitis medicine.disease Viral infection Virology Immunoglobulin G Flow cytometry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Immune system medicine.anatomical_structure chemistry Immunoglobulin class switching biology.protein medicine Immunology and Allergy B cell |
| Zdroj: | The Journal of Immunology. 197:1017-1022 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1500368 |
| Popis: | The role of Ab and B cells in preventing infection is established. In contrast, the role of B cell responses in containing chronic infections remains poorly understood. IgG2a (IgG1 in humans) can prevent acute infections, and T-bet promotes IgG2a isotype switching. However, whether IgG2a and B cell–expressed T-bet influence the host–pathogen balance during persisting infections is unclear. We demonstrate that B cell–specific loss of T-bet prevents control of persisting viral infection. T-bet in B cells controlled IgG2a production, as well as mucosal localization, proliferation, glycosylation, and a broad transcriptional program. T-bet controlled a broad antiviral program in addition to IgG2a because T-bet in B cells was important, even in the presence of virus-specific IgG2a. Our data support a model in which T-bet is a universal controller of antiviral immunity across multiple immune lineages. |
| Databáze: | OpenAIRE |
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