The addition of amines to diisobutylaluminum-imine complexes. Preparation of NPS R-568 Hydrochloride

Autor:	Sarah R. Logan, Robert M. Barmore, Bradford C. Vanwagenen
Rok vydání:	1998
Předmět:	Agonist chemistry.chemical_compound chemistry Hydrochloride medicine.drug_class Organic Chemistry Drug Discovery Imine medicine Organic chemistry chemistry.chemical_element Calcium Biochemistry
Zdroj:	Tetrahedron Letters. 39:3451-3454
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)00603-0
Popis:	A facile procedure for the preparation of secondary and tertiary amines from nitriles has been developed. The addition of amines to diisobutylaluminum-imine complexes derived by treating nitriles with DIBAL-H was found to proceed in moderate to good yields and was used to prepare NPS R-568 (1) hydrochloride, a potent calcium receptor agonist.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5ebf312f228e4d25dc60eda2aac4c322 https://doi.org/10.1016/s0040-4039(98)00603-0 Zobrazit plný text záznamu Full Text from ScienceDirect