Synthesis of the common left-half part of pectenotoxins

Autor:	Masanori Kobayashi, Azusa Okano, Fuyuki Yamamoto, Kenshu Fujiwara, Hidetoshi Kawai, Seiji Amano, Takanori Suzuki, Akio Murai, Yu-ichi Aki, Mariko Kawamura, Daisuke Awakura
Rok vydání:	2005
Předmět:	chemistry.chemical_compound Addition reaction Chemistry Organic Chemistry Drug Discovery Acetal Organic chemistry Biochemistry Left half Adduct
Zdroj:	Tetrahedron Letters. 46:5067-5069
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2005.05.062
Popis:	The common left-half [C31–C33(OC1–C7)–C40] part of pectenotoxins has been synthesized convergently from the C31–C35, C36–C40, and C1–C7 parts. The C31–C35 part, prepared via a new route shorter than our previous route, was coupled with the C36–C40 part through reductive lithiation and addition reactions to give an adduct stereoselectively, which was converted to a cyclic acetal corresponding to the C31–C40 part. The left-half was synthesized by a three-step process including esterification of the C31–C40 part with the C1–C7 part.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5e785f2b1e71108fb34abda2d3a650fd https://doi.org/10.1016/j.tetlet.2005.05.062 Zobrazit plný text záznamu Full Text from ScienceDirect