| Autor: |
Tiphany Chrun, Adam McNee, Matthew Edmans, Andrew K. Sewell, Garry Dolton, Beckie Clark, Elma Tchilian, Peter Beverley, Alain Townsend, Veronica Martini, Ronan MacLoughlin, Emmanuel Atangana Maze, Basu Paudyal, Alejandro Núñez |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.09.10.291625 |
| Popis: |
A vaccine providing both powerful antibody and cross-reactive T cell immune responses against influenza viruses would be beneficial for both humans and pigs. Here we evaluated intramuscular (IM), aerosol (Aer) and simultaneous immunization (SIM) by both routes in pigs, using the single cycle candidate influenza vaccine S-FLU. After prime and boost immunization pigs were challenged with H1N1pdm09 virus. IM immunized pigs generated high titer of neutralizing antibodies but poor T cell responses, while Aer induced powerful respiratory tract T cell responses, but a low titer of antibodies. SIM pigs combined high antibody titers and strong local T cell responses. SIM pigs showed the most complete suppression of virus shedding and the greatest improvement in pathology. We conclude that SIM regimes for immunization against respiratory pathogens warrant further study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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