Study on the therapeutic effects of low-energy laser therapy combined with cyclophosphamide on the mouse ascites sarcoma
| Autor: | Zhina Qu, Huanqi Liu, Xifeng Liu, Baoxu Huang, Hongbin Wang, Shaohui Cheng |
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| Rok vydání: | 2004 |
| Předmět: |
Drug
Pathology medicine.medical_specialty Dose Cyclophosphamide business.industry media_common.quotation_subject Therapeutic effect Cancer medicine.disease environment and public health enzymes and coenzymes (carbohydrates) embryonic structures Ascites cardiovascular system Cancer research Medicine Sarcoma medicine.symptom business Wound healing media_common medicine.drug |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.572054 |
| Popis: | By using the experimental model of mouse S180 ascites sarcoma, the feasibility and mechanism of low-energy laser therapy combined with the traditional antitumor drug of cyclophosphamide in the treatment of malignant tumors were discussed. The S180 ascites sarcoma suffering BALB/c mice were irradiated upon the Harder's glands with the dosages of 11.00, 14.67 and 22.00 J/cm2 respectively, and/or injected with CYT intraperitoneally to evaluate the therapeutic effects of CYT/LELT combination on malignant tumors. The three dosages of LELT combined with CYT all showed remarkably therapeutic effects on the mouse S180 ascites sarcoma. Comparatively, the dosage of 14.67J/cm2 LELT combined with CYT showed the most ideal therapeutic effects and the survival time was up to 20.80 days, and the life prolongation ratio was 33.33% which was remarkably higher than those of the CYT and tumor control groups. CYT/LELT combined therapy had remarkably inhibiting effects on the mice ascites growth because of the existence of CYT.© (2004) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only. |
| Databáze: | OpenAIRE |
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