| Popis: |
Intestinal dysbiosis, as a factor contributing to the development of sensitization to conditionally pathogenic flora of the intestines and aggrovates the clinical course of asthma, are paying a lot of attention. All new data suggest an association between food sensitivity and intestinal microflora. Effect of food intolerance and sensitivity for a bowel microbiome of allergy and respiratory diseases is of greate interest. We have tried to analyze the prevalence of lactase deficiency (LD) in patients with asthma. Identify the features of dysbiosis and determine the effect of the presence of LD on for the underlying phathology and the impact of treatment on intestinal microbiota LD and the underlying pathology. Methods: 70 patients with asthma were examined. All the studied caried a hydrogen breath test, lactose tolerance test, a study of polymorphism- 13910 C/T lactase gene (LPH); IgE total content, IgE specific to milk a cow; common Ig A, M, G; antibodies to Giardia, faces on dysbiosis, worm eggs and Giardia cysts; respiratory functions and ACT-test. Results: We identified 22 patients with LD and 2 patients with primary hypolactasia (C/C lactase gene). Giardians installed in 2 patients combinations with LD was not in these cases. In asthma in combination with LD average control figures for ACT- test lower than the group without asthma+ LD. The incidence of dysbiosis with LD was higher in comparision with isolated dysbiosis. There are also isolated cases of LD without dysbiosis. Conclusion: Lactase deficiency can influence the composition of intestinal microflora and create conditons for the worsening of asthma. LD should be considered as a factor burdening asthma control with the possible and necessary correction. |
