Is there a survival benefit with adjuvant radiotherapy in margin negative malignant phyllodes tumor of the breast after mastectomy? A single institutional study
| Autor: | Unna Runitha, Ranganathan Rama, Murhekar Kanchan, Iyer Priya, Balasubramanian Ananthi, Ganesarajah Selvaluxmy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Adjuvant radiotherapy business.industry Wide local excision medicine.medical_treatment Obstetrics and Gynecology Malignant phyllodes tumor 03 medical and health sciences Simple mastectomy 030104 developmental biology 0302 clinical medicine Survival benefit 030220 oncology & carcinogenesis Internal medicine medicine Radiology Nuclear Medicine and imaging Surgery Surgical treatment business Adjuvant Mastectomy |
| Zdroj: | Revista de Senología y Patología Mamaria. 34:214-219 |
| ISSN: | 0214-1582 |
| DOI: | 10.1016/j.senol.2021.03.001 |
| Popis: | Background and purpose This study aims to analyze the benefit of adjuvant radiotherapy (RT) in malignant phyllodes tumor in terms of overall survival and control of local and systemic recurrence. Recently, there is an increasing trend toward the use of adjuvant RT. Methods and material Fifty-four patients with non-metastatic, malignant phyllodes tumor from January 2001 to December 2015 were included in the study. All patients had undergone margin negative surgical treatment either with a wide local excision [ n = 6] or simple mastectomy [ n = 48]. Patients who received adjuvant RT were stratified as Group 1 [n = 29] and those who did not receive adjuvant radiation as Group 2 [n = 25]. Survival probabilities were estimated by the Kaplan–Meier method. Results The median follow-up was 76 months (2–150 months) with no statistically significant clinicopathologic or treatment factor associated with either local or systemic recurrence. There were seven [local 7.4% and systemic 5.6%] recurrences (3 in Group 1 and 4 in Group 2). The 5 and 10-year overall survival were 82% and 51% in Group 1 and 82% and 62% in Group 2, respectively (p = 0.989). Conclusion The role of adjuvant radiation in malignant phyllodes tumor in terms of overall survival is doubtful when margins are negative. |
| Databáze: | OpenAIRE |
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