Estimation of Glomerular Filtration Rate From Serum Cystatin C and Creatinine in Patients with Thyroid Dysfunction
| Autor: | Nikola Curic, Velibor Čabarkapa, Romana Mijovic, Branislava Ilincic, Radmila Žeravica, Zoran Stošić |
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| Rok vydání: | 2012 |
| Předmět: |
endocrine system
Creatinine medicine.medical_specialty endocrine system diseases biology business.industry Biochemistry (medical) Clinical Biochemistry Urology Renal function urologic and male genital diseases female genital diseases and pregnancy complications chemistry.chemical_compound chemistry Cystatin C Thyroid dysfunction Serum cystatin biology.protein Medicine In patient business |
| Zdroj: | Journal of Medical Biochemistry. 31:88-93 |
| ISSN: | 1452-8266 1452-8258 |
| DOI: | 10.2478/v10011-011-0044-0 |
| Popis: | Estimation of Glomerular Filtration Rate From Serum Cystatin C and Creatinine in Patients with Thyroid DysfunctionGiven that thyroid function influences serum cystatin C and creatinine levels, the question arises as to whether it is possible to accurately estimate glomerular filtration rate (GFR) in patients with thyroid dysfunction. The objective of the study was to determine serum cystatin C and creatinine levels and estimate GFR in patients with thyroid dysfunction. The study included 32 cases with newly diagnosed hyperthyroidism and 27 cases with newly diagnosed hypothyroidism, as well as 20 healthy controls matched for sex and age with the cases. Serum concentrations of thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4), creatinine and cystatin C were measured in all study subjects. GFR was estimated using the Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and cystatin C-based equations. Serum cystatin C levels were significantly higher in hyperthyroid subjects compared to controls (1.32±0.31 vs. 0.89±0.15; p2; p2; p |
| Databáze: | OpenAIRE |
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