Isocaloric intake of a high-fat diet promotes insulin resistance and inflammation in Wistar rats
| Autor: | Tatiane Mieko de Meneses Fujii, Patricia Silva Jacob, Monica Yamada, Marcelo Macedo Rogero, Ricardo Ambrósio Fock, Lucas Carminatti Pantaleão, Maria Carolina Borges, Primavera Borelli |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Glucose tolerance test medicine.diagnostic_test Cholesterol Insulin medicine.medical_treatment Clinical Biochemistry Insulin tolerance test C-reactive protein I-Kappa-B Kinase Cell Biology General Medicine Biology medicine.disease Biochemistry chemistry.chemical_compound Endocrinology Insulin resistance chemistry Internal medicine medicine biology.protein Protein kinase B |
| Zdroj: | Cell Biochemistry and Function. 31:244-253 |
| ISSN: | 0263-6484 |
| DOI: | 10.1002/cbf.2894 |
| Popis: | The aim of this study was to investigate the effect of isocaloric intake from a high-fat diet (HFD) on insulin resistance and inflammation in rats. Male Wistar rats were fed on an HFD (n = 12) or control diet (n = 12) for 12 weeks. Subsequently, all animals were euthanized, and blood glucose, insulin, free fatty acids, C-reactive protein, lipid profile, cytokines and hepatic-enzyme activity were determined. Carcass chemical composition was also analyzed. During the first and the twelfth weeks of the experimental protocol, the oral glucose tolerance test and insulin tolerance test were performed and demonstrated insulin resistance (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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