The effect of human platelet alloantigen polymorphisms on the in vitro responsiveness to adrenaline and collagen
| Autor: | Paul Metcalfe, Dimitris Loucopoulos, Panagiotis Economopoulos, Ekaterini Dimitriadou, Costas Christopoulos, Ilias Theodoropoulos |
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| Rok vydání: | 2001 |
| Předmět: |
endocrine system
Aspirin medicine.medical_specialty biology business.industry Hematology medicine.disease Thrombosis Human platelet antigen Pathogenesis Endocrinology Epinephrine Internal medicine Immunology medicine biology.protein Platelet Allele Antibody business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | British Journal of Haematology. 114:387-393 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.2001.02948.x |
| Popis: | A number of clinical studies have suggested that carriage of the low frequency allele (b) of the human platelet antigen 1 (HPA-1) system is a risk factor for coronary thrombosis. We have examined the effect of a series of HPA biallelic polymorphisms (systems -1, -2, -3 and -5) on the in vitro platelet aggregation in response to adrenaline and collagen in 30 healthy volunteers. There was a significantly higher prevalence (10 out of 18) of carriers of the HPA-1b polymorphism among subjects showing a > 50% aggregation response to adrenaline (‘responders’) than the prevalence (1/12) in ‘non-responders’ (P |
| Databáze: | OpenAIRE |
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