Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer’s disease patients and in normal cohorts from Russian populations

Autor: Sofia Golenkina, Vadim Stepanov, V. P. Puzyrev, A. Yu. Goltsov, Denis A. Reshetov, I. L. Kuznetsova, Selezneva Nd, Gavrilova Si, Gulnaz Faskhutdinova, A. E. Gareeva, Elza Khusnutdinova, L. M. Samokhodskaya, T. V. Andreeva, A. V. Kolotvin, I. V. Goldenkova-Pavlova, Evgeny I. Rogaev, A. Kazantseva, S. S. Kunizheva, I. Yu. Morozova, A. O. Vyacheslavova, L.I. Shagam, H. Shimshilashvili, Anastasia P. Grigorenko, Aigul Zainullina
Rok vydání: 2010
Předmět:
Zdroj: Molecular Biology. 44:546-551
ISSN: 1608-3245
0026-8933
DOI: 10.1134/s0026893310040072
Popis: Mutations in three genes PSEN1, PSEN2, and APP are known to be a cause of familial forms of Alzheimer's disease (AD). APOE gene polymorphism is a strong risk genetic factor for AD. We have evaluated allele and genotype frequency distribution of rs11136000 polymorphism in the clusterin (CLU) gene (or apo� lipoprotein J, APOJ) in the samples from three Russian populations and in AD patients. Genomewide asso� ciation studies in samples from several European populations have recently revealed the highly significant association of CLU gene with AD (p = 8.5 × 10 -10 ). We found no differences in allele and genotype frequencies of rs11136000 between the populations from the Moscow, Ural, and Siberia regions. The allele frequencies are close to those in European populations. The genetic association analysis in cohort of AD patients and nor� mal individuals (>500 individuals in each group) revealed no significant association of the rs11136000 poly� morphism in CLU gene with Alzheimer's disease in Russian populations. Although our results showed that the CLU gene polymorphism rs11136000 is likely not a major genetic factor for the common form of Alzhe� imer's disease, the data do not rule out the possibility of a modest effect of CLU and interaction between CLU and APOE genotypes in etiology of Alzheimer's disease.
Databáze: OpenAIRE
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