| Autor: |
Juli A. Wylegala, Michael D. Curley, Mirjana M. Lovrincevic, Beverly K. Philip, Trevor Szymanski, Massimo Ferrigno |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
The Open Anesthesiology Journal. 7:1-4 |
| ISSN: |
1874-3218 |
| DOI: |
10.2174/1874321801307010001 |
| Popis: |
As part of a study exploring the use of oral diazepam to reduce carbon dioxide production and extend survival in a disabled submarine, intranasal flumazenil was used repeatedly over 48 hours to intermittently reverse benzodiazepine-induced sedation in six adult male subjects. Previous reports of intranasal flumazenil have been limited to pediatric pa-tients. Here we report the time course of administration of intranasal flumazenil and its effects on adult subjects, in whom flumazenil was given during sedation/reversal/re-sedation cycles. Sedation scores increased with flumazenil administra-tion in 24 of the 30 cycles, and in 100% of cases when subjects were at deeper levels of sedation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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