Neuroproteomics Studies: Challenges and Updates
| Autor: | Firas Kobeissy, Mohamad El-Haress, Naify Ramadan, Hussein Ghazale, Mohammad El-Sayyad |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Computer science Mechanism (biology) Physiological condition Proteomics Data science Biomarker (cell) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neuroproteomics Proteome Human proteome project Biomarker (medicine) Human genome 030217 neurology & neurosurgery |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493969500 |
| Popis: | The Human Genome Project in 2003 has resulted in the complete sequence of ~99% of the human genome paving the road for the Human Proteome Project (HPP) assessing the full characterization of the translated protein map of the 20,300 protein-coding genes. Consequently, the emerging of the proteomics field has successfully been adopted as the method of choice for the proteome characterization. Proteomics is a term that is used to encompass multidisciplinary approaches combining different technologies that aim to study the entire spectrum of protein changes at a specific physiological condition. Proteomics research has shown excellent outcomes in different fields, among which is neuroscience; however, the complexity of the nervous systems necessitated the genesis of a new subdiscipline of proteomics termed as "neuroproteomics." Neuroproteomics studies involve assessing the quantitative and qualitative aspects of nervous system components encompassing global dynamic events underlying various brain-related disorders ranging from neuropsychiatric disorders, degenerative disorders, mental illness, and most importantly brain-specific neurotrauma-related injuries. In this introductory chapter, we will provide a brief historical perspective on the field of neuroproteomics. In doing so, we will highlight on the recent applications of neuroproteomics in the areas of neurotrauma, an area that has benefitted from neuroproteomics in terms of biomarker research, spatiotemporal injury mechanism, and its use to translate its findings from experimental settings to human translational applications. Importantly, this chapter will include some recommendation to the general studies in the area of neuroproteomics and the need to move from this field from being a descriptive, hypothesis-free approach to being an independent mature scientific discipline. |
| Databáze: | OpenAIRE |
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