AB1014 CLINICAL AND LABORATORY PHENOTYPES IN PATIENTS DIAGNOSED WITH SARCOIDOSIS IN A VETERAN’S HOSPITAL
| Autor: | Juan Manuel Bello-Gualtero, R. Reyes, D. Padilla-Ortiz, P. Medina, M. C. Romero, M. Carreno-Jaimes, D. Rincón-Riaño, Y. M. Chamorro-Melo |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Lung medicine.diagnostic_test business.industry Incidence (epidemiology) Medical record Immunology Disease medicine.disease General Biochemistry Genetics and Molecular Biology Confidence interval medicine.anatomical_structure Rheumatology Internal medicine Biopsy medicine Immunology and Allergy Sarcoidosis Chest radiograph business |
| Zdroj: | Annals of the Rheumatic Diseases. 79:1800.3-1800 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2020-eular.5672 |
| Popis: | Background:Sarcoidosis is a disease which affect any organ or tissue in the body, but is predisposed to lung involvement in up to 90% of cases. Its cause is not yet established, although a multicausal model with genetic, environmental and infectious factors is proposed.Objectives:Determine the clinical, paraclinical characteristics and survival of patients diagnosed with Sarcoidosis treated at the Central Military Hospital.Methods:Historical cohort study of patients who were diagnosed with Sarcoidosis at the Central Military Hospital in the last 5 years. A review of medical records, laboratory results and radiological studies was performed and verification of survival status free of mortality was documented by independent outcomes group. A descriptive analysis was done using standard methods and non-parametric survival was calculated using the Kaplan Meyer method with confidence interval in STATA 15.Results:Twenty patients with confirmatory biopsy of sarcoidosis. Average age 44 ± 15.3 years, 55% (11/20) of the patients were men. Dyspnea was the most frequent reason for consultation 50% (10/20), S. Löfgren 10% (2/20), the lung was the most frequent location 65% (13/20), mild hypercalcemia and normal enzyme converting angiotensin levels were found. 60% of patients had grade 1 commitment on the chest radiograph. 60% (12/20) of the patients received immunosuppressive treatment. The overall survival at 5 years was 92% (95% CI 57-99).Conclusion:Sarcoidosis is a disease of young patients with a slight predominance in men. Pulmonary involvement is the most frequent, followed by mediastinal nodal involvement. Most patients received steroid treatment at some time in their life. The long-term survival of the disease is more than 90%, which indicates its benign course.References:[1]Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis.N Engl J Med. 2007 Nov 22;357(21):2153-65.[2]Arkema EV, Grunewald J, Kullberg S, Eklund A, Askling J. Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden. Eur Respir J 2016; 48: 1690–1699.Acknowledgments:Not aplyDisclosure of Interests:None declared |
| Databáze: | OpenAIRE |
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