Reversed‐Phase High Performance Liquid Chromatographic Determination of Lipophilicity of Potential Antituberculosis Compounds

Autor:	Petr Kastner, Věra Klimešová, Jan Kresta, Jiri Klimes
Rok vydání:	2004
Předmět:	Chromatography Clinical Biochemistry Analytical chemistry Pharmaceutical Science Reversed-phase chromatography Biochemistry High-performance liquid chromatography Analytical Chemistry Partition coefficient chemistry.chemical_compound Benzothiazole chemistry Stationary phase Phase (matter) Lipophilicity Antibacterial agent
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 27:2539-2545
ISSN:	1520-572X 1082-6076
DOI:	10.1081/jlc-200028388
Popis:	Lipophilicity is one of the properties, which influences the partition of a substance in biological media. The reversed‐phase high performance liquid chromatography (RP‐HPLC) capacity factors k of 27 2‐benzylsulfanyl derivatives of benzothiazole, newly synthesized as potential antituberculous drugs, were determined on a C18 stationary phase with methanol–water as the mobile phase, using UV detection. The measured log k values were compared with the log P values obtained by means of mathematical methods. High correlation was found between log P and log k values.
Databáze:	OpenAIRE
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