Evaluation of scale-up strategies for the batch synthesis of dense and hollow mesoporous silica microspheres
| Autor: | Miloslav Lhotka, Marek Šoltys, František Štĕpánek, Martin Balouch, Pavel Ulbrich, Aleš Zadražil, Ondřej Kašpar, Pavel Kovačík |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
General Chemical Engineering Nanotechnology Sorption 02 engineering and technology General Chemistry Mesoporous silica 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Homogenization (chemistry) Industrial and Manufacturing Engineering 0104 chemical sciences Mesoporous organosilica Chemical engineering Pulmonary surfactant Specific surface area SCALE-UP Particle-size distribution Environmental Chemistry 0210 nano-technology |
| Zdroj: | Chemical Engineering Journal. 334:1135-1147 |
| ISSN: | 1385-8947 |
| Popis: | Despite the wide application interest in mesoporous silica micro- and nano-particles and a number of synthesis routes reported in the literature, the question of chemical engineering scale-up of the synthetic routes has rarely been addressed. The present work reports the results of an experimental and computational study of batch scale-up by a factor of 40× in the specific case of two types of dense and hollow mesoporous silica microparticles produced by the hydrolysis of tetraethoxysilane (TEOS) using a CTAB surfactant template. Volume and concentration based scale-up approaches have been investigated and systematically compared using a similarity index that included parameters related to the particle size distribution (d10, d50, d90) and pore structure (mean pore diameter, specific surface area, total pore volume, sorption hysteresis loop). The particle size distribution was found to be dependent mainly on the hydrodynamic conditions, expressed by the homogenization time, while the pore structure and the overall yield of the process were found to depend mainly on the CTAB/TEOS ratio. Overall, successful scale-up criteria in both volume and concentration based approaches have been identified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect