Heterogeneous hydrogenation of 1-naphtol and 2-naphtol over Ru/Al2O3: a simple 1H NMR method for determination of the diastereoselectivity

Autor:	François Garin, Arlette Solladié-Cavallo, Baram Ahmed, Michel Schmitt
Rok vydání:	2005
Předmět:	Proton chemistry Transition metal Bicyclic molecule Stereochemistry General Chemical Engineering Proton NMR Diastereomer chemistry.chemical_element General Chemistry Heterogeneous catalysis Medicinal chemistry Ruthenium
Zdroj:	Comptes Rendus Chimie. 8:1975-1980
ISSN:	1631-0748
Popis:	Heterogeneous hydrogenations of 1-naphthol and 2-naphthol over Ru/Al 2 O 3 -9001 (from Engelhard) are presented. It was found that 1-naphthol provides almost exclusively (98–100%) the cis -decalols (OH equatorial and axial) while the 2-naphthol lead to mixtures of a cis -decalol (OH equatorial) and a trans -decalol (OH equatorial) in 1/1–1/2 ratio where the trans -decalol is major. A rapid and simple 1 H NMR method (based on analysis of the patterns and of the 3 J values obtained from the C H (OH) proton) is described, which allows unambiguous assignment of the diastereomers of 1-decalols and 2-decalols. To cite this article: A. Solladie-Cavallo et al., C. R. Chimie (2005) .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5ab43a05ff0c5f9d808624f73a01339e https://doi.org/10.1016/j.crci.2005.06.005 Zobrazit plný text záznamu