Interaction between 2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine and enzymes of the NADPH-specific electron transport chain of rat liver microsomes
| Autor: | A. P. Shtokman, V. N. Kiseleva, T. N. Sniedze, T. I. Kagan, A. P. Gilev |
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| Rok vydání: | 1977 |
| Předmět: |
chemistry.chemical_classification
biology Cytochrome Chemistry Stereochemistry Dihydropyridine General Medicine Reductase biology.organism_classification Electron transport chain General Biochemistry Genetics and Molecular Biology Enzyme Microsoma Biochemistry In vivo biology.protein medicine Demethylase medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 83:794-797 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00798876 |
| Popis: | 2,6-Dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine interacts with the NADPH-dependent electron transport system of rat liver microsomes: It forms a type 1 complex with the terminal oxidase (cytochrome P-450) and also definitely inhibits the activity of NADPH-cytochrome c reductase and methindione demethylase. In experiments in vivo repeated administration of the compound had no inducing action on microsoma enzymes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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