Total Synthesis of Antibiotic (−)-Oudemansin X Utilizing L-Quebrachitol as a Chiral Pool

Autor:	Seiichiro Ogawa, Ken Yamada, Noritaka Chida
Rok vydání:	1992
Předmět:	Stereochemistry Cyclitol medicine.drug_class Antibiotics Absolute configuration Total synthesis General Chemistry chemistry.chemical_compound chemistry Oudemansin X medicine Organic chemistry Stereoselectivity Quebrachitol Enantiomer
Zdroj:	Chemistry Letters. 21:687-690
ISSN:	1348-0715 0366-7022
DOI:	10.1246/cl.1992.687
Popis:	The stereoselective conversion of naturally occurring optically active cyclitol, L-quebrachitol (2), into antifungal (E)-β-methoxyacrylate, oudemansin X is described. This synthesis fully confirmed the proposed absolute configuration of the antibiotic and revealed the usefulness of 2 as a versatile chiral pool.
Databáze:	OpenAIRE
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