| Autor: |
Birkeland Sa, Stephen Hamilton-Dutoit, H K Andersen |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Transplantation. 67:1209-1214 |
| ISSN: |
0041-1337 |
| DOI: |
10.1097/00007890-199905150-00002 |
| Popis: |
Background: A widely held view is that any increase in the potency of an immunosuppressive agent will lead to an increase in infection and malignancy, such as life-threatening Epstein-Barr virus (EBV) induced posttransplant lymphoproliferative disorders (PTLD). We tested this paradigm by studying the effect of adding mofetil to a steroid-free protocol under cover of high-dose aciclovir prophylaxis on the number of acute rejections, EBV infections and PTLDs after kidney transplantation. Methods: EBV serology was performed in 267 consecutive renal transplantations (1990-1997). All were treated with cyclosporine with an initial 10-day antilymphocyte globulin course, supplemented from September 1995 with MMF. In 208 consecutive transplantations after June 1992 aciclovir 3200 mg/day was given for 3 months posttransplantation. Results: After an observation period of up to 7 years we found that: (1) primary or reactivated EBV infection (PREBV) was correlated to acute rejection (treated with OKT3; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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