Optical fiber based in-vivo oxidative stress biosensor

Autor: Roman Kostecki, Abdeljalil El Habti, Bin Zhang, Heike Ebendorff-Heidepriem, Delphine Fleury, Mark R. Hutchinson, Penny J. Tricker, Roger J. Narayan, Azim Arman
Rok vydání: 2019
Předmět:
Zdroj: Biophotonics Australasia 2019.
DOI: 10.1117/12.2539920
Popis: Oxygen metabolism is a necessary process that takes place in animals and plants. Our cells and plant cells produce free radicals known as reactive oxygen species (ROS) continuously as a byproduct of oxygen metabolism and reaction to various environmental stresses, which must be normalized to avoid oxidative stress. Oxidative stress is intimately linked to cellular energy balance and occurs when there’s an imbalance between production and accumulation of ROS in cells and tissues and the ability of a biological system to keep in a redox steady state. We show preliminary results of an optical fiber based reversible in-vivo biosensor for understanding redox balance within living systems. The biosensor measured protein carbonyls (a marker of oxygen metabolism and oxidative stress) in pig-skin, live mouse, and wheat plant.
Databáze: OpenAIRE