| Autor: |
Raymond Bell, Robert J. Smith, Willem G. Linscheer, Chaidong Cho |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
Gastroenterology. 83:121-126 |
| ISSN: |
0016-5085 |
| DOI: |
10.1016/s0016-5085(82)80296-5 |
| Popis: |
Alpha-chain disease with involvement of small intestine resulting in characteristic villus atrophy and malabsorption has not been reported in this country. We studied a 57-yr-old male who presented with a polypoid tumor of the hepatic flexure of the colon. There was no evidence of malabsorption as manifested by a normal fat balance, serum carotene, and D-xylose absorption studies and the small bowel biopsy did not show villus atrophy. The tumor in the colon was surgically removed and diagnosed as a malignant lymphoma of lymphocytic type. Tumor tissue infiltrated in the mesentery could not be excised. Alpha-chain disease protein was demonstrated in serum and urine, and also in tumor tissue by immunoperoxidase techniques. The α-chain disease protein was further purified and classified as subclass 1. The patient had a good clinical response to cyclophosphamide and prednisone, but still has intraabdominal lymphoma with gastric involvement, and his serum α-chain protein persists. This case report may represent a distinct variant of α-chain disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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