Scrapie: A Virus-Induced Amyloidosis of the Brain

Autor: Markus Czub, Henk R. Braig, Heino Diringer
Rok vydání: 2007
Předmět:
Zdroj: Ciba Foundation Symposium 135-Novel Infectious Agents and the Central Nervous System
DOI: 10.1002/9780470513613.ch9
Popis: We have studied the pathogenesis of scrapie in hamsters, in particular the increase of infectivity and the formation of scrapie-associated fibrils in relation to clinical disease. The results of such studies after intraperitoneal or intracerebral infection are consistent with the idea that transmissible spongiform encephalopathies are a type of virus-induced, brain-specific amyloidosis. Therefore, an appropriate name for the class of viruses that cause these diseases might be amyloid-inducing viruses.
Databáze: OpenAIRE