Intraoperative phototherapy: A comparative study of intravenous and topical photofrin II and aminolevulinic acid

Autor:	Davis Rk, Sun Y, R C Straight
Rok vydání:	1997
Předmět:	medicine.medical_specialty business.industry medicine.medical_treatment medicine.disease Dermatology Animal tumor Otorhinolaryngology medicine Adjuvant therapy Surgery Fibrosarcoma business Photofrin II Adjuvant
Zdroj:	Otolaryngology - Head and Neck Surgery. 116:223-227
ISSN:	0194-5998
DOI:	10.1016/s0194-5998(97)70329-2
Popis:	This study compares the systemic and topical application of photofrin II and aminolevulinic acid as an intraoperative adjuvant therapy in the C3H mouse radiation-induced fibrosarcoma model. Dose-development and time-dependent studies were first conducted followed by intraoperative phototherapy studies with photofrin II and aminolevulinic acid. Study results clearly show that intraoperative phototherapy after aminolevulinic acid topical application is significantly more effective than treatment with photofrin II given intravenously or topically (p < 0.05) in this animal tumor model. The concept of topical application of photosensitizers and the rationale for intraoperative adjuvant phototherapy are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::57c9cbf87f1398277e72035918cdd2c4 https://doi.org/10.1016/s0194-5998(97)70329-2 Zobrazit plný text záznamu Plný text