A Novel Chemoselective Cleavage of (tert-Butyl)(dimethyl)silyl (TBS) Ethers Catalyzed by Ce(SO4)2⋅4 H2O

Autor:	Carlos A. González-González, Davir González-Calderón, Erick Cuevas-Yañez, David Corona-Becerril, Carlos González-Romero, Aydeé Fuentes-Benítez
Rok vydání:	2014
Předmět:	Tert butyl chemistry.chemical_classification Silylation Organic Chemistry Cleavage (embryo) Biochemistry Medicinal chemistry Catalysis Inorganic Chemistry chemistry Intramolecular force Drug Discovery Organic chemistry Physical and Theoretical Chemistry Alkyl
Zdroj:	Helvetica Chimica Acta. 97:965-972
ISSN:	0018-019X
Popis:	(tert-Butyl)(dimethyl)silyl (tBuMe2Si; TBS) phenyl/alkyl ethers were efficiently cleaved to the corresponding parent hydroxy compounds in good yields using catalytic amounts of Ce(SO4)2⋅4 H2O by microwave-assisted or conventional heating in MeOH. Intramolecular and competitive experiments demonstrated the chemoselective deprotection of TBS ethers in the presence of triisopropylsilyl (iPr3Si; TIPS) and (tert-butyl)(diphenyl)silyl (tBuPh2Si; TBDPS) ethers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::578357f3f09d2cb88acbc2e5c33a5e2a https://doi.org/10.1002/hlca.201300354 Zobrazit plný text záznamu Plný text ve formátu PDF