353-OR: Comparison of Methods for Classifying Heterogeneity in Gestational Diabetes (GDM) and Association with Outcomes
| Autor: | David A. Sacks, David McIntyre, Kristen Gibbons, Patrick M. Catalano, Wing H. Tam, Lene Ring Madsen, Ronald C.W. Ma |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pregnancy
medicine.medical_specialty endocrine system diseases business.industry Obstetrics Endocrinology Diabetes and Metabolism Concordance Confounding nutritional and metabolic diseases Hypoglycemia medicine.disease Gestational diabetes Diabetes mellitus Cohort Internal Medicine medicine Hyperinsulinemia business |
| Zdroj: | Diabetes. 68 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db19-353-or |
| Popis: | An underlying principle of the IADPSG GDM classification is that women at similar risk of adverse pregnancy outcomes related to hyperglycemia should be classified similarly. Powe et al have described heterogeneous GDM phenotypes related to impaired insulin secretion and/or insulin sensitivity and reported that pregnancy complications relate primarily to impaired insulin sensitivity. However, their Gen3G cohort was largely Caucasian and GDM women received treatment. Our study was designed to further examine this hypothesis in a diverse population of 6128 untreated women from 5 centers in the blinded epidemiologic HAPO study. Following similar methodology (Impairment = parameter value Disclosure D. McIntyre: None. L.R. Madsen: None. K.S. Gibbons: None. D.A. Sacks: None. R.C. Ma: Advisory Panel; Self; Boehringer Ingelheim International GmbH. Research Support; Self; AstraZeneca, Bayer AG, Pfizer Inc. Stock/Shareholder; Self; GemVCare. Other Relationship; Self; AstraZeneca. W.H. Tam: None. P. Catalano: None. |
| Databáze: | OpenAIRE |
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