| Autor: |
Sachio Fushida, Satoshi Wakama, Akiyoshi Mizumoto, Shunsuke Motoi, Masumi Ichinose, Nobuyuki Takao, Shouzou Sako, Yutaka Yonemura, Kousuke Noguchi, Emel Canbay, Haruaki Ishibashi, Yang Liu |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Surgery. 4 |
| DOI: |
10.29011/2575-9760.001214 |
| Popis: |
Summary Background: Neoadjuvant Intraperitoneal/ Systemic Chemotherapy (NIPS) is considered effective method to treat Peritoneal Metastasis (PM) from Gastric Cancer (GC). The objective of the present study is to verify the effect of NIPS on Lymph Node Metastasis (LNM). Methods: During the last 18 years, we enrolled 107 and 136 patients who underwent D2-gastrectomy after NIPS and D2-gastrectomy alone (non-NIPS group), respectively. Results: The total number of LNMs in the non-NIPS group and NIPS group was 14.8 ± 13.9 and 4.6 ± 5.9, respectively (P NIPS is a very effective method to control LNM from GC. After intraperitoneal administration of chemotherapeutic drug, extremely higher concentrations of chemotherapeutic drug are absorbed through omental milky spots, and the efferent lymphatic fluid drain into the regional lymph nodes of stomach. As a result, regional LNM of stomach are exposed with extremely higher concentrations of chemotherapeutic drugs than systemic chemotherapy. This feature of the lymphatic circulation accounts for the much greater effects of NIPS on LNM. Synopsis: Neoadjuvant intraperitoneal/systemic chemotherapy is effective not only peritoneal metastasis but also lymph node metastasis from gastric cancer. Keywords: Gastric cancer; Lymph node metastasis; Neoadjuvant intraperitoneal/systemic chemotherapy |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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