| Autor: |
Xiaohai Zhang, J. Michael Cecka, Nicole Valenzuela, Elaine F. Reed, Qiuheng Zhang, Michelle J. Hickey, James H. Lan |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Practical Atlas of Transplant Pathology ISBN: 9783319230535 |
| DOI: |
10.1007/978-3-319-23054-2_1 |
| Popis: |
Disparity of human leukocyte antigen (HLA) molecules between a transplant recipient and a donor elicits the generation of alloreactive T and B cells that mediate graft rejection. Matching HLA of the donor and recipient reduces alloreactivity and prolongs graft survival in organ transplants. However, only few transplants are actually performed between HLA-identical individuals, and life-long immunosuppression is needed to prevent graft rejection. Accurate assessment of immunological risk factors coupled with precise tools for diagnosis and classification of rejection is critical for successful treatment and prevention of rejection. HLA testing has evolved substantially over the last 50 years with the advent of comprehensive molecular HLA typing and sensitive solid-phase HLA antibody identification assays that enable new strategies for donor-recipient risk assessment. This chapter provides an overview of the HLA system and mechanisms underlying allograft rejection. We also discuss the diagnostic tests performed by the Immunogenetics Laboratory to assess risk, diagnose transplant rejection, and guide immunosuppressive therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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