Effect of compliance with nicotine gum dosing on weight gained during a quit attempt
| Autor: | Joseph G. Gitchell, Saul Shiffman, Arthur J. Garvey, Jeffrey M. Rohay, Stuart G. Ferguson |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
business.industry media_common.quotation_subject Medicine (miscellaneous) Abstinence Placebo Placebo group Surgery Nicotine Psychiatry and Mental health Nicotine gum Internal medicine medicine Active treatment Dosing medicine.symptom business Weight gain media_common medicine.drug |
| Zdroj: | Addiction. 106:651-656 |
| ISSN: | 0965-2140 |
| DOI: | 10.1111/j.1360-0443.2010.03244.x |
| Popis: | Aim Using nicotine gum can reduce the amount of weight gained when quitting. Here we examine the relationship between weight gain and use of adequate amounts of gum. To mitigate the confounders associated with correlational analyses, we contrast the effects of active gum and placebo, and analyze outcomes prospectively. Design and setting Randomized double-blind placebo-controlled trial of nicotine gum. Participants were instructed to use nine to 15 pieces of gum/day for the first 2 months of treatment. Participants Participants (n = 103) were randomized to either active (2 mg or 4 mg) or placebo gum. Measurements We examined the effect on weight gain of the interaction between treatment (active versus placebo) and daily gum use [－9 pieces/day (compliant use) versus < 9 pieces/day]. Findings After 30 days of abstinence, smokers treated with active gum had not gained significantly less weight than those on placebo (1.1 kg versus 1.6 kg, P = 0.175). However, a significant compliance・treatment interaction was observed (P = 0.005): active gum users who used －9 pieces/day during the first 14 days of treatment had gained less weight at follow-up (0.6 kg versus 1.6 kg for those who used |
| Databáze: | OpenAIRE |
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