Modification of Clinoptilolite with Benzalkonium Chloride as a Carrier of Metformin Hydrochloride

Autor:	I.G.A.W. Kusumawati, A.W. Permadi, I.M.W.A. Putra
Rok vydání:	2019
Předmět:	Clinoptilolite Chemistry 02 engineering and technology General Chemistry Metformin Hydrochloride 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Benzalkonium chloride medicine 0210 nano-technology medicine.drug Nuclear chemistry
Zdroj:	Asian Journal of Chemistry. 31:1275-1278
ISSN:	0975-427X 0970-7077
Popis:	Clinoptilolites have a limitation in the adsorption of drug molecules due to their fixed pore structure. In this study, we modified the clinoptilolite with benzalkonium chloride. The modification was carried out by stirring 1 g of NaCl activated clinoptilolite with 100 mL of benzalkonium chloride solution with a concentration of 0.5, 1, 5, 10 and 15 % at room temperature for 24 h. After filtration and drying process, benzalkonium chloride modified clinoptilolite was stirred with 100 mL of 300 mg/L metformin hydrochloride solution at room temperature for 24 h. The result of sample characterization using FTIR spectrometer, X-ray diffractometer and N2 Sorption analyzer showed that clinoptilolite modification with benzalkonium chloride and the impregnation of metformin hydrochloride proceeded well. The optimal amount of metformin hydrochloride occurred in benzalkonium chloride 1 % modified clinoptilolite.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::56225e3bedee08a9cc17111a9755b2e5 https://doi.org/10.14233/ajchem.2019.21887 Zobrazit plný text záznamu