Dynamic epidermal cooling in conjunction with laser-induced photothermolysis of port wine stain blood vessels

Autor:	Thomas E. Milner, B. Samuel Tanenbaum, Sol Kimel, J. Stuart Nelson, Bahman Anvari, Lars O. Svaasand
Rok vydání:	1996
Předmět:	Pulsed laser Pathology medicine.medical_specialty Dye laser Materials science integumentary system Port-wine stain Dermatology medicine.disease Laser law.invention law Skin surface medicine Surgery Congenital disease Biomedical engineering
Zdroj:	Lasers in Surgery and Medicine. 19:224-229
ISSN:	1096-9101 0196-8092
DOI:	10.1002/(sici)1096-9101(1996)19:2<224::aid-lsm15>3.0.co;2-6
Popis:	When a cryogen spurt is applied to the skin surface for an appropriately short period of time (on the order of tens of milliseconds), the spatial distribution of cooling remains localized in the normal overlying epidermis, while leaving the temperature of the deeper port wine stain (PWS) blood vessels unchanged. Furthermore, cooling continues after pulsed laser exposure as cryogen remaining on the surface evaporates and removes heat deposited by light absorption in epidermal melanin. An additional advantage of dynamic cooling is a reduction in the level of pain and discomfort associated with flashlamp-pumped pulsed dye laser therapy of PWS. Preliminary clinical studies and supporting theoretical calculations demonstrate the feasibility of selective epidermal cooling while achieving photothermolysis of blood vessels during pulsed laser treatment of PWS.
Databáze:	OpenAIRE
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