SINGLE NUCLEOTIDE POLYMORPHISM –11391 G>A OF ADIPONECTIN GENE (ADIPOQ) IN TYPE 2 DIABETES PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
| Autor: | Zh. A. Leshchenko, Yu. I. Karachentsev, T. V. Tyzhnenko, M. Y. Gorshunska, V. V. Poltorak, L. O. Atramentova, N. S. Krasova, E. Jаnsen, I. V. Chernyavskaya, N. O. Kravchun, A. O. Cherniaieva, O. O. Plohotnichenko, A. K. Pochernyayev, O. V. Zemlyanitcyna, O. I. Gladkih, Y. A. Opaleiko |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Candidate gene Adiponectin business.industry Endocrinology Diabetes and Metabolism Fatty liver Single-nucleotide polymorphism Type 2 diabetes medicine.disease Pathology and Forensic Medicine Endocrinology Diabetes mellitus Internal medicine medicine SNP business Allele frequency |
| Zdroj: | Problems of Endocrine Pathology. 49:7-17 |
| ISSN: | 2518-1432 2227-4782 |
| DOI: | 10.21856/j-pep.2014.3.01 |
| Popis: | It was studied the single nucleotide polymorphism (SNP) in the promoter region of –11391 G > A adiponectin gene (ADIPOQ) in patients with type 2 diabetes (n = 223) and healthy inhabitants of Kharkiv (n = 51). It was established the absence of significant differences in allele frequency for SNP –11391 G > A in patients with type 2 diabetes (pG = 0.856 pA = 0.144 ), diabetes mellitus patients complicated with non-alcoholic fatty liver disease (pG = 0.850 pA = 0.150 ) and healthy individuals (pG = 0.911 pA = 0.088 ). According to the results of the study the contribution of genetic components in the propensity formation for the development of non-alcoholic fatty liver disease in patients with diabetes in SNP –11391 G > A gene ADIPOQ was not identified. The data obtained have proved promising of further research, which should be based on a study of the role of other candidate genes in the development of non-alcoholic fatty liver disease and their relationship with various metabolic parameters which may allow clarifying the role of genes in disease formation |
| Databáze: | OpenAIRE |
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