Elevated Alpha1-Antichymotrypsin Serum Levels in a Subset of Nondemented First-Degree Relatives of Alzheimer's Disease Patients
| Autor: | James Schmeidler, Larry D. Altstiel, Brian A. Lawlor, Arthur Dalton, Richard C. Mohs, Kenneth L. Davis, Pankesh Mehta |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Pathology biology business.industry Cognitive Neuroscience Acute-phase protein medicine.disease Gastroenterology Alpha 1-antichymotrypsin Pathophysiology Central nervous system disease Psychiatry and Mental health Degenerative disease Internal medicine Severity of illness medicine biology.protein Geriatrics and Gerontology Alzheimer's disease First-degree relatives business |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 6:17-20 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000106917 |
| Popis: | A portion of Alzheimer''s disease (AD) patients have elevated serum levels of the acute phase reactant α1-antichymotrypsin (A1ACT) compared to age-matched controls. We measured serum levels of A1ACT in AD patients, age-matched controls, Down''s Syndrome patients, and nondemented first-degree relatives of AD patients. Significantly elevated levels of A1ACT were found in both AD patients and first-degree-relatives. In AD patients, serum A1ACT concentrations decreased with increasing severity of cognitive impairment. These results may suggest that inflammatory phenomena may be an early component of AD pathophysiology. |
| Databáze: | OpenAIRE |
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