Fine Needle Aspiration Cytology of Endocrine Neoplasms of the Pancreas
| Autor: | Ana Pérez-Campos, Pilar González-Peramato, José A. Jiménez-Heffernan, Pilar López-Ferrer, Blanca Vicandi, José M. Viguer |
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| Rok vydání: | 2004 |
| Předmět: |
Pathology
medicine.medical_specialty Histology medicine.diagnostic_test biology business.industry Chromogranin A General Medicine medicine.disease Pathology and Forensic Medicine Pancreatic endocrine tumor medicine.anatomical_structure Fine-needle aspiration Paraganglioma Pancreatic tumor Biopsy Endocrine neoplasm medicine biology.protein Pancreas business |
| Zdroj: | Acta Cytologica. 48:295-301 |
| ISSN: | 1938-2650 0001-5547 |
| DOI: | 10.1159/000326376 |
| Popis: | Objective To analyze the role of fine needle aspiration (FNA) cytology in the preoperative diagnosis of pancreatic endocrine neoplasms. Methods Cytologic and histologic diagnoses of pancreatic endocrine tumors were reviewed. A total of 20 FNA cytologic procedures from 20 patients were selected. A false positive case, a retroperitoneal paraganglioma, was also reviewed. Two groups of patients were established: (1) those in whom a surgical biopsy with an immunohistochemical study was available (n = 13), and (2) those with a pancreatic tumor in which the diagnosis was confirmed by immunocytochemical studies (n = 7). In 13 cases the pancreatic tumor was aspirated, while in 7, liver metastases were studied. The immunoexpression of chromogranin and synaptophysin was evaluated in alcohol-fixed smears from 12 and 11 cases, respectively. Results One false negative and 1 false positive diagnosis were present. In the remaining 19 cases a cytologic diagnosis of pancreatic endocrine tumor was given. Main cytologic features were: (1) a prominent cellular dissociation with many single cells and small, poorly cohesive groups; (2) intermediate to large size cells with ill-defined cytoplasm, naked or eccentric nuclei, and frequent binucleation; and (3) variable nuclear pleomorphism with the characteristic finely granular distribution of the chromatin. Immunocytochemical evidence of endocrine differentiation (chromogranin or synaptophysin) was present in the 12 cases analyzed. Conclusion FNA cytology offers the possibility of a precise preoperative, noninvasive diagnosis of pancreatic endocrine tumors. Cytologic features differ considerably from those of pancreatic adenocarcinoma, allowing differentiation from nonfunctioning endocrine neoplasms. In difficult cases immunocytologic studies are very helpful. |
| Databáze: | OpenAIRE |
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