| Autor: | Tania Wiens, Denise Lafreniere, Raymond T. Bartus, S. R. Winn, Yunhua Hu, Brant P. Hasler, Pamela Snodgrass, Joanne Marsh, Dwaine F. Emerich |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Organic Chemistry Pharmaceutical Science Rodent model medicine.disease Biodegradable polymer Carboplatin Surgery Microsphere chemistry.chemical_compound chemistry Glioma medicine Cancer research Molecular Medicine Pharmacology (medical) business Biotechnology |
| Zdroj: | Pharmaceutical Research. 17:767-775 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1007576405039 |
| Popis: | Purpose. Implantation of biodegradable polymers provides a powerfulmethod to deliver high, sustained concentrations of chemotherapeuticsto brain tumors. The present studies examined the ability of injectablepolymeric microspheres, formulated to release carboplatin or BCNUfor 2–3 weeks, to enhance survival in a rodent model ofsurgically-resected glioma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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