Antibacterial and cytotoxicity effects of biogenic palladium nanoparticles synthesized using fruit extract of Couroupita guianensis Aubl
| Autor: | Sathishkumar Gnanasekar, Balakrishnan Dhivyabharathi, Pradeep K. Jha, Prabukumar Seetharaman, Sivaramakrishnan Sivaperumal, Jeyaraj Murugaraj, Ravikumar Vilwanathan, Varunkumar Krishnamoorthy |
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| Rok vydání: | 2018 |
| Předmět: |
Couroupita guianensis
Reducing agent Health Toxicology and Mutagenesis Biomedical Engineering Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences General Biochemistry Genetics and Molecular Biology Absorbance Dynamic light scattering Artificial Intelligence Organic chemistry General Pharmacology Toxicology and Pharmaceutics Fourier transform infrared spectroscopy Aqueous solution General Immunology and Microbiology biology Chemistry General Neuroscience technology industry and agriculture General Medicine 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Surface modification 0210 nano-technology General Agricultural and Biological Sciences Nuclear chemistry |
| Zdroj: | Journal of Applied Biomedicine. 16:59-65 |
| ISSN: | 1214-0287 1214-021X |
| DOI: | 10.1016/j.jab.2017.10.001 |
| Popis: | Herein, we report a facile route to synthesize palladium nanoparticles (CGPdNPs) using the aqueous fruit extract of C. guianensis Aubl. as a potent biological reducing agent. Reduction of PdCl2 solution into their nano scale was confirmed with the formation of a black precipitate which gives a reduced absorbance in UV–vis spectroscopy. Fourier transform infrared spectroscopy (FTIR) reveals the active role of phenolic constituents from C. guianensis in reduction and surface functionalization of nanoparticles (NPs). Dynamic light scattering (DLS) and zeta potential analysis confirms the generation of polydispersed highly stable NPs with large negative zeta value (−17.7 mV). Interestingly, X-ray Diffraction (XRD) pattern shows that the synthesized CGPdNPs were face centered cubic crystalline in nature. The HRTEM micrographs of CGPdNPs displays well-dispersed, spherical NPs in the size ranges between 5 and 15 nm with an average of 6 nm. It was also noticed that the synthesized CGPdNPs possess an effective antimicrobial activity against different bacterial pathogens. On the other hand, in vitro cell viability (MTT) assays reveals that the synthesized CGPdNPs exhibited an extraordinary anticancer properties. Eventually, hemocompatibility assay depicts the safe nature of synthesized NPs for biomedical application. |
| Databáze: | OpenAIRE |
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