Intramolecular conversion of N,N-bis(2-picolyl)ureas to cyclic carbamates

Autor:	Willi Bannwarth, Uwe Jakob
Rok vydání:	2015
Předmět:	Organic Chemistry chemistry.chemical_element Ring (chemistry) Biochemistry Copper Medicinal chemistry Solvent chemistry.chemical_compound chemistry Intramolecular force Yield (chemistry) Drug Discovery Amine gas treating Urea derivatives Acetonitrile
Zdroj:	Tetrahedron Letters. 56:6340-6344
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2015.09.118
Popis:	Herein, we present a new methodology for preparing 6-membered ring carbamates from a Cu I -promoted cyclization of N , N -bis(2-picolyl)amine substituted ureas. The reactions work best in the presence of up to five-fold excess of CuCl at room temperature in a non-nucleophilic solvent such as acetonitrile. Nine examples of the syntheses are presented to yield products in good to excellent amounts.
Databáze:	OpenAIRE
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