Chronic exposure to ethylenethiourea induces kidney injury and polycystic kidney in mice
Autor: | Won-Chul Cho, Jae Seok Song, Byong-Gon Park, Hwa-Kyoung Chung, Hye Yeon Park, Daeho Kwon, Woon-Seob Shin, Seung Hee Choi |
---|---|
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Health Toxicology and Mutagenesis Nephron Toxicology Creatine Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fibrosis Internal medicine Medicine General Pharmacology Toxicology and Pharmaceutics Blood urea nitrogen Hydronephrosis Ethylenethiourea Kidney medicine.diagnostic_test business.industry Public Health Environmental and Occupational Health medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry 030220 oncology & carcinogenesis business Lipid profile |
Zdroj: | Molecular & Cellular Toxicology. 15:57-63 |
ISSN: | 2092-8467 1738-642X |
DOI: | 10.1007/s13273-019-0007-y |
Popis: | Ethylenethiourea (ETU) is one of the main metabolite of ethylenebisdithiocarbamate fungicides and potential exposure is highest for workers involved in rubber and fungicide production. Exposure of ETU induces endocrine disruption, teratogenesis, carcinogenicity, and goitrogenicity. ETU was administrated at concentration of 2 mg/kg/day for 58 weeks in C57BL/6 mice. After 58 weeks, blood samples were analyzed serum lipid profile, hepatic function dices, and plasma levels of creatine and blood urea nitrogen. Isolated kidneys were stained with haematoxylin-eosin. Analysis of miRNA expression profile was conducted on Affymetrix miRNA 4.0 Array. Chronic diet of ETU induced body weight loss, increased serum triglyceride and total cholesterol, increased plasma creatine and blood urea nitrogen, injured glomerulus and nephron tubule, induced severe hydronephrosis and polycystic kidney. ETU diet increased expression levels of the biomarker of renal injury and fibrosis in kidney. miR-17~92 cluster and miR-182-5p associated with cyst progression were increased in expression levels on the kidney. Chronic exposure to ETU at low concentrations results in functional and structural damage to the kidney, and increases cyst formation in the kidney. |
Databáze: | OpenAIRE |
Externí odkaz: |