Effectiveness and Safety of Treatment with Nucleo(s)tide Analogues in Patients with Hepatitis B-related Cirrhosis
| Autor: | Klimentina Gerdzhikova, Ivo Donkov, Teodora Komitova, Jordan Genov, Borislav Vladimirov, Rumyana Mitova, Milena Chetirska, Boryana Asenova, Ali Bedran, Kaloyan Pavlov |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Proceedings of the Bulgarian Academy of Sciences. 75:1063-1071 |
| ISSN: | 2367-5535 1310-1331 |
| DOI: | 10.7546/crabs.2022.07.15 |
| Popis: | Data from Bulgaria are limited on the long-term effects of nucleo(s)tide analogues (NAs) to patients with hepatitis B-related cirrhosis. The study aimed to evaluate the overall efficacy and renal safety of NAs in such cohort of patients, comparing treated with high to low-barrier NAs. We retrospectively analyzed 58 patients with HBV cirrhosis (74.1% in compensated stage) for a period of 5 years. Thirty-five patients received NAs with high-barrier of resistance: Tenofovir disoproxil fumarate and Entecavir (followed up for 51.63 ± 30.3) and 23 received NAs with low-barrier of resistance: Lamivudine and Telbivudine (followed up for 56.7 ± 48.4). After a median treatment time of 53.7 months virological response (VR) rates (HBV DNA |
| Databáze: | OpenAIRE |
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