Metabolic Surgery and Class 1 Obesity (< 35 kg/m2): a Prospective Study with Short-, Mid-, and Long-term Results Among Latinos
| Autor: | Luis Cevallos, Gianluca Donatini, Antonio Herrera, Lizbeth Guilbert, Elisa M. Sepúlveda, Fátima M. Rodríguez, Carlos Zerrweck |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Weight loss Internal medicine Diabetes mellitus medicine Prospective cohort study education education.field_of_study Nutrition and Dietetics business.industry Type 2 Diabetes Mellitus medicine.disease Obesity chemistry 030211 gastroenterology & hepatology Surgery Glycated hemoglobin medicine.symptom business Body mass index |
| Zdroj: | Obesity Surgery. 31:2401-2409 |
| ISSN: | 1708-0428 0960-8923 |
| DOI: | 10.1007/s11695-021-05275-3 |
| Popis: | Metabolic surgery for managing class 1 obesity and type 2 diabetes mellitus has recently gained popularity. The Latino population presents high rates of these diseases. Reports on surgical outcomes in this population are scarce. Prospective study with Mexican patients diagnosed with diabetes and class 1 obesity submitted to Roux-en-Y gastric bypass. The objective was to determine short-, mid-, and long-term outcomes (weight loss, metabolic, morbidity, and diabetes remission). Sub-analysis was included, based on preoperative usage of one (group A) or more (group B) oral hypoglycemic agents ± insulin. Fifty-one patients with a mean body mass index of 33.1 ± 1.9 kg/m2, and glycated hemoglobin 7.2 ± 1.7% were included. Significant improvements were observed in almost every parameter. At 24, 36, and 60 months, complete diabetes remission was achieved in 73.8%, 52.2%, and 50% of patients with glycated hemoglobin levels of 5.7% ± 0.8%, 5.8% ± 0.5%, and 6.1% ± 0.8%, respectively. At 24, 36, and 60 months, patients in group A (N=28) showed 90.9%, 69.2%, and 75% remission, respectively, versus patients in group B (N=23), who had remission rates of 50%, 30%, and 25% during the same period. Diabetes relapse was higher in patients using ≥ 2 oral hypoglycemic agents ± insulin before surgery. Gastric bypass is a safe and effective metabolic surgery that results in excellent mid- and long-term results among Mexicans. Patients using one drug preoperatively showed improved results and remission rates, which underscores the importance of intervening in the early stages of the disease. Clinical Trials identifier: NCT04595396 ( www.ClinicalTrials.gov ). |
| Databáze: | OpenAIRE |
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