| Autor: |
Uno Hideo, Itami Satoshi, Inui Shigeki, Pan Huei-Ju, Chang Eugene, Takayasu Susumu, Ye Fangfang, Imamura Koji, Kurata Sotaro, Seki Toshihiko, Ideta Ritsuro, Aoki Hirohumi, Adachi Kenji, Vera Price, Loretta Collins, Cynthia A. Heinlein, Chang Chawnshang |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Androgens and Androgen Receptor ISBN: 9781461354222 |
| DOI: |
10.1007/978-1-4615-1161-8_19 |
| Popis: |
In addition to male sexual development and maturation, androgens also mediate sebum secretion and hair growth. The effect of androgens is mainly through their binding to the androgen receptor (AR) which is a nuclear receptor superfamily member. These androgen-AR complexes then enhance their target genes’ expression by binding to response elements in the promoter region of those target genes (Chang et al., 1988). Some androgen actions require intracellular conversion of testosterone (T) to 5α-dihydrotestosterone (DHT) by steroid 5α-reductase in the target tissue. It has become clear that AR transcriptional activity can be modulated by interacting coregulatory proteins, either with an enhancing effect (coactivators) or a reducing effect (corepressors), and that these coregulators have little influence on the basal transcription rate (reviewed in McKenna et al.9 1999). The AR coregulators could be general for steroid hormone receptors (such as with the SRC family) (Onate et al., 1995) or more specific for AR (reviewed in Heinlein, et al., Chapter 4). These AR coregulators can enhance AR transactivation through different kinds of mechanisms including enhancing ligand binding (i.e. ARA70) (Ting and Chang, unpublished observations), enhancing the interaction between the AR N-terminal and C-terminal (i.e. CBD) (Ikonen et al., 1997), influencing AR nuclear-cytoplasmic trafficking (i.e. ARA24) (Gorlich et al., 1999), or through unknown mechanisms (i.e. supervillin) (Ting et al., 2001). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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