Introduction of a closed-system cell processor for red blood cell washing: postimplementation monitoring of safety and efficacy
| Autor: | Adele L. Hansen, Jason P. Acker, Nayana Sondi, Qi-Long Yi, Christine Cserti-Gazdewich, Barbara Hannach, Jacob Pendergrast |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Erythrocyte transfusion
medicine.medical_specialty Transfusion service business.industry Immunology Blood preservation Beta thalassemia Hematology 030204 cardiovascular system & hematology medicine.disease Surgery 03 medical and health sciences Inventory management Red blood cell 0302 clinical medicine medicine.anatomical_structure Anesthesia Clinical endpoint medicine Immunology and Allergy business 030215 immunology Allogeneic transfusion |
| Zdroj: | Transfusion. 56:49-57 |
| ISSN: | 0041-1132 |
| DOI: | 10.1111/trf.13341 |
| Popis: | BACKGROUND After introduction of a closed-system cell processor, the effect of this product change on safety, efficacy, and utilization of washed red blood cells (RBCs) was assessed. STUDY DESIGN AND METHODS This study was a pre-/postimplementation observational study. Efficacy data were collected from sequentially transfused washed RBCs received as prophylactic therapy by β-thalassemia patients during a 3-month period before and after implementation of the Haemonetics ACP 215 closed-system processor. Before implementation, an open system (TerumoBCT COBE 2991) was used to wash RBCs. The primary endpoint for efficacy was a change in hemoglobin (Hb) concentration corrected for the duration between transfusions. The primary endpoint for safety was the frequency of adverse transfusion reactions (ATRs) in all washed RBCs provided by Canadian Blood Services to the transfusion service for 12 months before and after implementation. RESULTS Data were analyzed from more than 300 RBCs transfused to 31 recipients before implementation and 29 recipients after implementation. The number of units transfused per episode reduced significantly after implementation, from a mean of 3.5 units to a mean of 3.1 units (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text