An Overview of Thrombosis and Platelet Involvement in the Development of the Human Atherosclerotic Plaque
| Autor: | A. Bleakley Chandler |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pathology
medicine.medical_specialty Endothelium business.industry Fatty streak medicine.disease Thrombosis Lesion medicine.anatomical_structure cardiovascular system medicine Platelet cardiovascular diseases Thrombus medicine.symptom business Process (anatomy) circulatory and respiratory physiology Calcification |
| Zdroj: | Pathobiology of the Human Atherosclerotic Plaque ISBN: 9781461279686 |
| DOI: | 10.1007/978-1-4612-3326-8_24 |
| Popis: | Thrombi that form on the walls of arteries may persist to become incorporated into the intima and thereby participate in atherogenesis. As a mural thrombus is incorporated by overgrowth of new endothelium, it may be converted to plaque tissue by arterial wall cells, which organize the thrombus. The main cells that organize a thrombus are intimal smooth muscle or myointimal cells. Unresolved and unorganized remnants of a thrombus may undergo fatty change and calcification. Thus, as a thrombus is converted to an atherosclerotic plaque it loses its identity and the lesion becomes decreasingly recognizable as thrombotic in origin. During the thrombotic process, platelets react with the arterial wall and participate in the formation of thrombi. Platelets, as well as monocytes, which also occur in thrombi (1), might contribute further to atherogenesis by the release of growth factors that stimulate the proliferation of intimal smooth muscle cells (2, 3), which are a prominent feature of atherosclerotic plaques (4–6). These cells take part in early plaque development and are present in fatty streaks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|