Clinical evaluation of chronic liver diseases induced by different hepatitis C virus genotype in Japan, focused on the difference between genotypes III/2a and IV/2b

Autor: Kaori Fujii, Chisa Murakami, Fumio Tsuda, Kiwamu Okita, Masaaki Korenaga, Muneko Okazaki, Makoto Mayumi, Keisuke Hino, Michiari Okuda, Hiroaki Okamoto
Rok vydání: 1999
Předmět:
Zdroj: Hepatology Research. 14:204-211
ISSN: 1386-6346
DOI: 10.1016/s1386-6346(99)00002-9
Popis: It remains controversial if hepatitis C virus (HCV) genotypes in the same genetic group or type are different in the activity of viral replication and capacity to induce severe clinical disease. HCV genotypes and HCV RNA titers were determined in consecutive 264 patients with chronic liver disease in Yamaguchi, Japan. Genotype I/1a was detected in 3 (1%), II/1b in 192 (74%), III/2a in 46 (18%), IV/2b in 17 (6%) and co-infection with II/1b and III/2a in 3 (1%); HCV RNA titers in the remaining three patients were too low to be genotyped. The patients with genotype III/2a were significantly older (P
Databáze: OpenAIRE