An Unusual Metastatic Motilin-Secreting Neuroendocrine Tumour with a 20-Year Survival
| Autor: | T L Peeters, Stanislas Pauwels, Jacques Rahier, P. De Clercq, Birgit Weynand, Pierre Henri Deprez, E. Wibin, René Fiasse |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Pathology Gastric emptying business.industry medicine.medical_treatment digestive oral and skin physiology Gastroenterology Motility Neuroendocrine tumors medicine.disease Metastasis Motilin Endocrinology Somatostatin Internal medicine medicine Pancreatic polypeptide Hepatectomy business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Digestion. 64:255-260 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000048870 |
| Popis: | Motilin-secreting neuroendocrine tumours have been rarely described. Immunohistochemical, biochemical and motility investigations were performed in a 62-year-old man with liver and bone metastases of a motilin-secreting neuroendocrine tumour originating from a rectal polyp removed 14 years previously. Symptoms related to liver metastases were reduced by a right hepatectomy whereas plasma motilin levels were decreased. The patient also underwent two operations for spinal cord decompression and survived 6 more years under medical treatment, mainly octreotide. Immunohistochemistry revealed predominant expression of motilin-containing cells, with rare cells expressing somatostatin and pancreatic polypeptide, and staining for only one panendocrine marker, neurone-specific enolase. A liver tumour extract contained 17.9 µg motilin per gram of tissue, which permitted to isolate and characterize human motilin, which was identical to porcine motilin. Plasma column gel chromatography revealed a main peak corresponding apparently to porcine motilin. The patient had no symptoms of disturbed motility. Gastric emptying and gastroduodenojejunal motility were found within normal limits. The absence of alterations of gut motility was perhaps related to sustained autonomous motilin production. The long evolution of this type of tumour suggests that plasma motilin determination should be added to the investigations for neuroendocrine tumours. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|